Search results for "Classic Kaposi Sarcoma"

showing 9 items of 9 documents

Risk of Classic Kaposi Sarcoma With Combinations of Killer Immunoglobulin-Like Receptor and Human Leukocyte Antigen Loci: A Population-Based Case-con…

2015

BACKGROUND Kaposi sarcoma (KS) is a complication of KS-associated herpesvirus (KSHV) infection. Other oncogenic viral infections and malignancies are associated with certain HLA alleles and their natural killer (NK) cell immunoglobulin-like receptor (KIR) ligands. We tested whether HLA-KIR influences the risk of KSHV infection or KS. METHODS In population-based case-control studies, we compared HLA class I and KIR gene frequencies in 250 classic (non-AIDS) KS cases, 280 KSHV-seropositive controls, and 576 KSHV-seronegative controls composing discovery and validation cohorts. Logistic regression was used to calculate sex- and age-adjusted odds ratios (ORs) and 95% confidence intervals. RESUL…

0301 basic medicineGenotypevirusescase-control studyPopulationchemical and pharmacologic phenomenaHuman leukocyte antigenBiologyLymphocyte ActivationSettore MED/42 - Igiene Generale E ApplicataMajor Articles and Brief Reports03 medical and health sciencesReceptors KIRnatural killer–cell immunoglobulin-like receptorsHLA AntigensRisk FactorsSeroepidemiologic Studieshuman leukocyte antigenGenotypeotorhinolaryngologic diseasesHLA-B AntigensHumansImmunology and AllergySeroprevalenceGenetic Predisposition to Diseasehuman geneticeducationSarcoma Kaposieducation.field_of_studyClassic Kaposi SarcomaCase-control studyvirus diseasesKaposi sarcomaOdds ratiomajor histocompatibility complex030104 developmental biologyInfectious DiseasesGene Expression RegulationItalyCase-Control StudiesItaly; Kaposi sarcoma; case-control study; human genetics; human leukocyte antigens; major histocompatibility complex; natural killer–cell immunoglobulin-like receptorsHerpesvirus 8 HumanImmunologyJournal of Infectious Diseases
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A Common Genetic Variant inFCGR3A-V158F and Risk of Kaposi Sarcoma Herpesvirus Infection and Classic Kaposi Sarcoma

2005

Associations of FCGR3A among men with HIV/acquired immunodeficiency syndrome suggest that host responses affect the pathogenesis of Kaposi sarcoma herpesvirus (KSHV) infection and risk of acquired immunodeficiency syndrome – associated Kaposi sarcoma. Using DNA from two HIV seronegative case-control populations in Italy, we examined whether the functional FCGR3A-V158F variant was associated with risk of KSHV infection or classic Kaposi sarcoma (CKS). In population I, we examined FCGR3A variants and risk of KSHV infection in 34 KSHV latent nuclear antigen (LANA)-seropositive and 120 LANAseronegative adults from Sardinia (52% male; median age, 45 years; range, 31-60), whereas in population II…

AdultMaleEpidemiologyPopulationmedicine.disease_causeVirusHerpesviridaeAcquired immunodeficiency syndrome (AIDS)Risk FactorsOdds RatiomedicineHumansRisk factoreducationSarcoma KaposiAgedAged 80 and overeducation.field_of_studyClassic Kaposi Sarcomabusiness.industryReceptors IgGCase-control studyGenetic Variationvirus diseasesHerpesviridae InfectionsOdds ratioMiddle Agedmedicine.diseaseVirologyItalyOncologyCase-Control StudiesHerpesvirus 8 HumanImmunologybusinessCancer Epidemiology, Biomarkers & Prevention
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Associations of classic Kaposi sarcoma with common variants in genes that modulate host immunity

2006

AbstractClassic Kaposi sarcoma (CKS) is an inflammatory-mediated neoplasm primarily caused by Kaposi sarcoma–associated herpesvirus (KSHV). Kaposi sarcoma lesions are characterized, in part, by the presence of proinflammatory cytokines and growth factors thought to regulate KSHV replication and CKS pathogenesis. Using genomic DNA extracted from 133 CKS cases and 172 KSHV-latent nuclear antigen-positive, population-based controls in Italy without HIV infection, we examined the risk of CKS associated with 28 common genetic variants in 14 immune-modulating genes. Haplotypes were estimated for IL1A, IL1B, IL4, IL8, IL8RB, IL10, IL12A, IL13, and TNF. Compared with controls, CKS risk was decrease…

AdultMaleGenotypeEpidemiologyPopulationSingle-nucleotide polymorphismBiologySettore MED/42 - Igiene Generale E ApplicataIL12AmedicineHumansGenetic Predisposition to DiseaseRisk factoreducationSarcoma KaposiAgedAged 80 and overeducation.field_of_studyClassic Kaposi SarcomaPolymorphism GeneticCase-control studyCancerHerpesvirus InfectionOdds ratioMiddle Agedmedicine.diseaseOncologyHaplotypesItalyGenetic VariantCase-Control StudiesImmunologyHerpesvirus 8 HumanCytokinesFemaleClassic Kaposi Sarcoma
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Risk Factors for Classical Kaposi Sarcoma in a Population-based Case-control Study in Sicily

2008

Abstract Background: Classical Kaposi sarcoma is a rare complication of Kaposi sarcoma-associated herpes virus (KSHV) infection. We conducted a population-based, frequency-matched case-control study in Sicily to further investigate the reported inverse relationship between smoking and classical Kaposi sarcoma and to identify other factors associated with altered risk. Methods: All incident, histologically confirmed classical Kaposi sarcoma cases in Sicily were eligible. A two-stage cluster sample design was applied to select population controls. KSHV seropositivity was determined using four antibody assays (K8.1 and orf73 enzyme immunoassays and two immunofluorenscence assays). Using SAS-ca…

AdultMalemedicine.medical_specialtyEpidemiologyPopulationSettore MED/42 - Igiene Generale E ApplicataArticleRisk FactorsInternal medicinemedicineCKS risk factors SicilyHumanseducationSarcoma KaposiSicilyAgedAged 80 and overeducation.field_of_studyChi-Square DistributionClassic Kaposi Sarcomabusiness.industryIncidenceIncidence (epidemiology)SmokingCase-control studyvirus diseasesCancerOdds ratioMiddle Agedmedicine.disease/dk/atira/pure/subjectarea/asjc/2700/2730Logistic ModelsOncologyCase-Control Studies/dk/atira/pure/subjectarea/asjc/2700/2713ImmunologyFemaleSarcomabusinessChi-squared distribution
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Risk of classic Kaposi sarcoma with exposures to plants and soils in Sicily

2010

Abstract Background Ecologic and in vitro studies suggest that exposures to plants or soil may influence risk of Kaposi sarcoma (KS). Methods In a population-based study of Sicily, we analyzed data on contact with 20 plants and residential exposure to 17 soils reported by 122 classic KS cases and 840 sex- and age-matched controls. With 88 KS-associated herpesvirus (KSHV) seropositive controls as the referent group, novel correlates of KS risk were sought, along with factors distinguishing seronegatives, in multinomial logistic regression models that included matching variables and known KS cofactors - smoking, cortisone use, and diabetes history. All plants were summed for cumulative exposu…

Cancer ResearchPathologymedicine.medical_specialtyClassic Kaposi Sarcomabusiness.industryEpidemiologyvirus diseasesfood and beveragesPhysiologymedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensSettore MED/42 - Igiene Generale E Applicatalcsh:RC254-282lcsh:Infectious and parasitic diseasesInfectious DiseasesOncologySoil watermedicinelcsh:RC109-216SarcomabusinessHERPESVIRIDAE KAPOSI SARCOMA ITALY ECOLOGY PLANTS NATURAL PRODUCTS SOILSResearch ArticleInfectious Agents and Cancer
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Differences in Kaposi sarcoma-associated herpesvirus-specific and herpesvirus-non-specific immune responses in classic Kaposi sarcoma cases and match…

2011

Kaposi sarcoma (KS) might develop because of incompetent immune responses, both non-specifically and specifically against the KS-associated herpesvirus (KSHV). Peripheral blood mononuclear cells from 15 classic (non-AIDS) KS cases, 13 KSHV seropositives (without KS) and 15 KSHV-seronegative controls were tested for interferon-γ T-cell (enzyme-linked immunospot [Elispot]) responses to KSHV-latency-associated nuclear antigen (LANA), KSHV-K8.1 and CMV/Epstein-Barr virus (EBV) peptide pools. The forearm and thigh of each participant was also tested for delayed-type hypersensitivity (DTH) against common recall antigens. Groups were compared with Fisher exact test and multinomial logistic regress…

Cancer ResearchvirusesT-LymphocytesEnzyme-Linked Immunosorbent AssayBiologyAntibodies ViralSettore MED/42 - Igiene Generale E ApplicataPeripheral blood mononuclear cellArticleInterferon-gammaViral ProteinsImmune systemAntigenInterferonmedicineHumansInterferon gammaHypersensitivity DelayedAntigens ViralSarcoma KaposiSicilyGlycoproteinsKSHV SicilyClassic Kaposi SarcomaELISPOTvirus diseasesNuclear ProteinsAntigens NuclearGeneral Medicinebiochemical phenomena metabolism and nutritionmedicine.diseaseVirologyImmunity InnateKaposi sarcoma; HHV8; ELISPOT; immune responseOncologyCase-Control StudiesImmunologyHerpesvirus 8 HumanLeukocytes MononuclearSarcomamedicine.drug
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Risk of classic Kaposi sarcoma with residential exposure to volcanic and related soils in Sicily

2009

Purpose Before AIDS, endemic (African) Kaposi sarcoma (KS) was noted to occur in volcanic areas and was postulated to result from dirt chronically embedded in the skin of the lower extremities. The primary cause of all KS types is KS-associated herpesvirus (KSHV) infection, but cofactors contribute to the neoplasia. We investigated whether residential exposure to volcanic or related soils was associated with the risk of classic Kaposi sarcoma (cKS) in Sicily. Methods Risk of incident cKS ( N  = 141) compared with population-based KSHV seropositive controls ( N  = 123) was estimated for residential exposure to four types of soil, categorized with maps from the European Soil Database and dire…

MaleEpidemiologyPopulationClassic KS volcanic soil SicilyVolcanic EruptionsSettore MED/42 - Igiene Generale E ApplicataArticleSoilResidence CharacteristicsRisk FactorsWater SupplyEnvironmental healthmedicineHumansTephraeducationSarcoma KaposiKaposi's sarcomaAgedAged 80 and overeducation.field_of_studyClassic Kaposi Sarcomabusiness.industrySoil classificationEnvironmental ExposureOdds ratioEnvironmental exposuremedicine.diseaseSoil typeItalyImmunologyEnvironmental PollutantsFemalebusiness
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Prevalence of Toscana and Sicilian Phlebovirus Antibodies in Classic Kaposi Sarcoma Case Patients and Control Subjects in Sicily

2011

To assess whether arthropod bites promote Kaposi sarcoma (KS), we determined the seroprevalence of Sicilian (SFSV) and Toscana (TOSV) phlebovirus antibodies in 30 patients with classic KS and 100 controls in Sicily. Nine (6.9%) subjects, all controls, were positive for SFSV, whereas 41 (31.5%) were positive for TOSV. Seroprevalence with immunoglobulin (Ig) M or IgG against either virus was significantly higher in controls (43% vs 13.3% in case patients; P < .01). Adjusted for age, IgG seroprevalence was significantly lower in KS patients compared to controls (adjusted odds ratio, 0.22; 95% confidence interval, .07–.72). Low phlebovirus seroprevalence in patients with KS may reflect incapaci…

MalePhlebovirusphlebovirus classic Kaposi sarcoma SicilyComorbidityBiologyAntibodies ViralSettore MED/42 - Igiene Generale E ApplicataImmunoglobulin GVirusMajor Articles and Brief ReportsSeroepidemiologic StudiesHumansImmunology and AllergySeroprevalenceSarcoma KaposiAgedAged 80 and overClassic Kaposi SarcomaOdds ratioMiddle Agedbiology.organism_classificationVirologyInfectious DiseasesImmunoglobulin MItalyPhlebovirusImmunoglobulin MImmunoglobulin GHerpesvirus 8 HumanImmunologybiology.proteinFemaleAntibodyThe Journal of Infectious Diseases
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Delayed-type hypersensitivity in classic Kaposi sarcoma patients and controls

2011

Background: Immune perturbation likely affects the development of Kaposi sarcoma (KS) among people infected with the KS-associated herpesvirus (KSHV). We tested whether KSHV-seropositive individuals or cases of classic KS (cKS), which typically originates in the leg, had differing delayed-type hypersensitivity (DTH) in the forearm or leg. Methods: Mantoux DTH with three antigens (Candida, tetanus, PPD) was performed on the forearm and leg of 15 cKS cases, 14 KSHV-positives without KS, and 15 KSHV-negative controls. The diameters of induration responses were compared by group and body site. Results: Leg DTH was greater than forearm DTH among controls (mean difference 5.6 mm, P=0.0004), where…

MaleherpesvirusesCancer ResearchAllergyherpesvirusedelayed-type hypersensitivitySettore MED/42 - Igiene Generale E ApplicataForearmAntigenImmunopathologymedicineHumansHypersensitivity DelayedSarcoma KaposiAgedLegClassic Kaposi Sarcomaintegumentary systembusiness.industryKaposi sarcomamedicine.diseasebody regionsTransplantationForearmhuman immunodeficiency virus (HIV)medicine.anatomical_structureOncologyItalyDelayed hypersensitivityHerpesvirus 8 HumanImmunologyClinical StudyFemaleSarcomabusinesstransplantation
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